KPV

KPV (Lys-Pro-Val) is a naturally occurring tripeptide derived from the C-terminal sequence (positions 11–13) of alpha-melanocyte-stimulating hormone (α-MSH). Research has identified KPV as the minimal active fragment responsible for α-MSH's anti-inflammatory signalling properties, and unlike the full-length hormone, KPV does not exhibit melanocortin receptor agonist activity, making it a unique tool for studying inflammation pathways independently of MC receptor activation. Published studies have investigated KPV's effects on NF-κB nuclear translocation, IL-1β and TNF-α expression in macrophage cell lines, and intestinal epithelial barrier function in Caco-2 monolayer models. Supplied as a >99% purity lyophilised powder (10mg).

This product is intended strictly for laboratory research use only. It is not approved for human or veterinary consumption or for use in diagnostic or therapeutic procedures.

• Purity: >99%
• Form: Lyophilised powder
• Intended use: Laboratory research only